Stage-Dependent Levels of Brain-Derived Neurotrophic Factor and Matrix Metalloproteinase 9 in the Prognosis of Colorectal Cancer
نویسندگان
چکیده
Purpose: The development of sensitive and non-invasive biomarkers for the early detection CRC determination their role in individual stages CRC. Methods: MMP-9 expression serum tissue, BDNF plasma were detected using ELISA method. tissue also determined by immunohistochemical staining. Results: To assess balance between changes survival tumor progression, we compared BDNF/MMP-9 ratios tissues living deceased individuals. ratio (evaluated immunohistochemically) decreased significantly with progression disease patients. was statistically reduced II III to benign group. However, individuals, showed an opposite tendency. Conclusion: BDNF/MMP9 can be used as a prognostic biomarker
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2023
ISSN: ['2227-9059']
DOI: https://doi.org/10.3390/biomedicines11071839